Research Topic: Mental Health
On-going Research Projects:
A Psychophysiologic Study of Weakening Traumatic Combat Memories With Post-Reactivation
This research will study the effects of propranolol administered in combination with tramatic memory reactivation as a potential treatment for PTSD.

Biomarkers of Risk for Post-Traumatic Stress Disorder (PTSD)
This research will try to identify genetic biomarkers of risk for PTSD.

Components of Effective Suicide Prevention in the US Air Force
This research will determine the effectiveness of the Air Force Suicide Prevention Program (AFSPP).

Early Intervention Research Program to Enhance Soldier Resilience
This study will compare the effectiveness of various types of early intervention (debriefing, information, cognitive-behavioral) following a potentially traumatizing event, in order to develop valid methods to improve soldier resilience after such events.

Efficacy of Adjunct Sleep Interventions for PTSD (EASI-PTSD)
This project will investigate two different interventions for sleep disturbances associated with PTSD in men and women veterans.

Longitudinal Risk and Resilience Factors Predicting Psychiatric Disruption, Mental Health Service Utilization, and Military Retention in OIF National Guard Troops
This research will measure deployment experiences (such as combat exposure, other deployment-related stressors, perceptions of unit support, and use of in-theater combat stress interventions) and post-deployment psychiatric distress, quality of life, life stressors, mental health service utilization, and military retention/attrition over the course of 2 years.

Neurobiology of Severe Psychological Trauma in Women
This study will review the effects of mental trauma on normal brain functioning in women with post-traumatic stress disorder.

Neuroendocrine Correlates of PTSD Before and After Treatment
This project will examine biological and psychological alterations in veterans with post-traumatic stress disorder (PTSD) before and after treatment.

Online Early Resilience Intervention for Combat-Related PTSD in Military Primary Healthcare Settings: A Randomized Trial of DESTRESS-PC
This study is an innovative use of Internet-based technology and may provide a unique early combat-related PTSD intervention and resilience training option for military personnel and veterans seeking primary care after experiencing combat-related stressors.

Online Early Resilience Intervention for Combat-Related PTSD in Military Primary Healthcare Settings: A Randomized Trial of DESTRESS-PC
This study is an innovative use of Internet-based technology and may provide a unique early combat-related PTSD intervention and resilience training option for military personnel and veterans seeking primary care after experiencing combat-related stressors.

Predictors of Treatment Response to Fluoxetine in PTSD Following a Recent History of War Zone Stress Exposure
This study will give us some of the information needed to target treatment of PTSD in soldiers that need help to be able to appropriately function in the military or civilian worlds.

Risperidone Treatment for Military Service Related Chronic Post-Traumatic Stress Disorder
This project will determine if Risperidone reduces PTSD symptoms, relative to a placebo, in veterans with military service related chronic PTSD who have been partial or non-responders to antidepressant medications.


Completed Research Projects:
A Comparison of PTSD Symptomatology among Three Army Medical Units Involved in ODS
This study tested individuals from reserve units involved in Operation Desert Storm for symptoms related to post-traumatic stress disorder.

A Placebo-Controlled Trial of Prazosin vs. Paroxetine in Combat Stress-Induced PTSD Nightmares and Sleep Disturbance
This project conducted a clinical trial to determine how effective Prazosin compared to Paroxetine is for combat stress-induced PTSD nightmares and sleep disturbance.

A Prospective Study of Suicide Prevention in the US Air Force
This project investigated whether the USAF Suicide Prevention Program reduced the number of suicides over time.

A Randomized Clinical Trial for Cognitive-Behavioral Treatment for PTSD in Women (See DoD-125)
This study compared the ability of two types of treatment for mental and emotional disorders for women with military-related posttraumatic stress disorder.

A Randomized Clinical Trial of Cognitive-Behavioral Treatment for PTSD in Women
This study evaluated the efficacy of cognitive-behavioral therapy (CBT) for post-traumatic stress disorder (PTSD) in women.

A Randomized Clinical Trial of Cognitive-Behavioral Treatment for PTSD in Women (See VA-74)
This study reviewed two different types of treatment for women with military-related posttraumatic stress disorder (PTSD).

A Randomized, Multi-Center, Controlled Trial of Multi-Model Therapy in Veterans with Gulf War Illness (EBT) (See also DoD-115; formerly VA/DoD 1V)
This project studied Gulf War veterans who had unexplained chronic medical symptoms such as pain, fatigue, and/or cognitive difficulties.

A Randomized, Multi-Center, Controlled Trial of Multi-Model Therapy in Veterans with Gulf War Illnesses (CBT) (See also VA-62; formerly VA/DoD 1D)
This study looked at whether or not cognitive behavioral therapy (CBT) and aerobic exercise, alone or in combination, are better than regular care for Gulf War veterans with chronic unexplained symptoms.

Acupuncture for the Treatment of Trauma Survivors
The purpose of this study was to determine the effectiveness of acupuncture as a treatment for Posttraumatic Stress Disorder (PTSD) among military personnel.

Acute and Long-Term Impact of Deployment to Southwest Asia on the Physical and Mental Health of Soldiers and their Families
This study looked at the short and long-term impact of deployment to Southwest Asia on the physical and mental health of soldiers and their families.

Clinical Relevance of Novel Immunological Markers in PTSD
This study looked at the possible relationship between a certain protein and post-traumatic stress disorder (PTSD) in Vietnam War veterans.

Demonstrating the Efficacy of Scenario-Based Virtual Reality Tools for Treatment of Acute PTSD in Non-Combat Arms Personnel
This study compared virtual reality therapy to the current standard treatment- combination of medications and cognitive behavior therapy- for treating acute PTSD.

Desert Storm Reunion Survey
This project examined patterns of readjustment of Gulf War veterans following their return from the Gulf region.

Development of a Family-Based, Post-Deployment Intervention
This project developed an intervention for returning military personnel and their families, especially their partners.

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; A Study of Symptoms Among 1500 Seabees
This study compared post-war symptoms and diseases of Gulf War-era deployed veterans to non-deployed veterans.

Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 5: Seabee Health Study
This study compared symptoms and illnesses between Gulf War veterans and other veterans.

Epidemiological Studies Persian Gulf War Illnesses, PG Women's Health Linkage Study
This study compared the general health of Gulf War era women who deployed to those who did not deploy.

Evaluation of Cognitive Functioning of Persian Gulf Veterans
This project reviewed self-reported health complaints and environmental exposures in the Persian Gulf region.

Family Study of Fibromyalgia
The primary goal of this study was to examine the relationship between fibromyalgia and mental disorders within families.

Feasibility of Developing a Registry of PTSD Affected Veteran Sib Pairs
This study examined the possibility of developing a database of veteran sibling pairs to look at possible genetic associations with PTSD.

Follow-Up Investigation of Troops Exposed to Nerve Agents at Aberdeen Proving Ground (Pilot Study) (See also VA-63A; formerly VA/DoD-2DA)
This pilot study surveyed individuals exposed to chemical agents for common neurological and mental health disorders to determine whether or not a full study of health effects on exposed individuals can be done.

Follow-Up Investigation of troops exposed to nerve agents at Aberdeen Proving Ground (Pilot Study) (See also DoD-116A; formerly VA/DoD-2VA/2DA)
This study was done to determine if it was possible to follow up on soldiers exposed to chemical agents.

Follow-up of Psychological and Neurocognitive Gulf War Outcome: Relation to Stress
The purpose of this study was to continue to examine mental illness and brain function in Gulf War veterans with and without PTSD.

HPA Axis Alterations in PTSD: A Comparison of Gulf War and Vietnam Veterans
Not available.

HPA Axis Reactivity in Men and Women with Chronic PTSD
This study was designed to evaluate the brain functions in men and women with chronic post-traumatic stress disorder.

Illness Among Persian Gulf War Veterans: Case Validation Studies
This study compared confirmed illnesses of Gulf War veterans to veterans who did not deploy to the Gulf.

Impaired Auditory Sensory Gating, Acoustic Startle Response: Effects of Long and Short Deployments on Army Combat Readiness
This project studied "post-deployment" soldiers of OEF/OIF.

Improving Outcomes of Depression in Primary Care
This study reviewed the impact of a low-intensity care management program on outcomes of patients with major depression.

Interactions of Subsymptomatic Doses of Sarin with Pyridostigmine: Neurochemical, Behavioral, and Physiological Effects
This animal study tested the effects of low level exposure of sarin and pyridostigmine bromide (PB) on the brain and nervous system functions of rats.

Longitudinal Health Study of Gulf War Veterans
This study assessed the health status of Gulf War veterans and non-Gulf War veterans to determine if the Gulf War veterans health status are better, worse or the same as non-Gulf War veterans ten or more years after the war.

Magnetic Resonance and Spectroscopy of the Human Brain in Gulf War Illnesses
This study interviewed and examined groups of Gulf War veterans with and without unexplained illnesses to determine whether abnormalities in the brain imaging of ill Gulf War veterans (by magnetic resonance spectroscopy), occur independently of posttraumatic stress disorder, alcohol dependence, and depression.

Measurement and Validation of Psychosocial Risk and Resilience Factors Accounting for Physical and Mental Health and Health-Related Quality of Life among PGWVs
This study compared self-reported symptoms and health-related quality of life among Gulf War veterans to determine if these factors could be associated with deployment.

Memory and Attention in PTSD
This project compared two groups of PTSD sufferers (one Vietnam-era, one Gulf War era) to a group of veterans with no PTSD symptoms.

Multisample Study of the Natural Course of PTSD Symptoms
This project investigated the natural course of Posttraumatic Stress Disorder (PTSD).

Neurological and Circadian Substrates of PTSD-like Behaviors
This study was designed to determine if the development of post-traumatic stress disorder requires both a traumatic event and a genetic increased risk.

Neuroplasticity and Calcium Signaling in Stressed Rat Amygdala
This animal study looked at the ability of rats brains to recover function after being exposed to stress.

Neuropsychological Functioning in Persian Gulf Era Veterans
This study evaluated the brain function and mental health of some Gulf War veterans who sought treatment.

Neuropsychological Functioning in Veterans
This project compared learning, memory, and attention performances in groups of Gulf War returnees with and without PTSD diagnosis.

Outreach Intervention for OIF Veterans to Promote Use of Mental Health Services
This research studied an intervention to encourage returning soldiers with behavioral health disorders to obtain treatment.

Outreach Intervention for OIF Veterans to Promote Use of Mental Health Services
This research studied an intervention to encourage returning soldiers with behavioral health disorders to obtain treatment.

Parental Wartime Deployment on Adjustment in Children
This project studied the various affects on children with a deployed parent.

Physical, Mental, Social, and Family Health Outcomes of Gulf War Veterans
This study compared the physical, social, mental, and family health of Gulf War veterans to military personnel who deployed and did not deploy to other regions of the world.

Physiologic Effects of Stress in Gulf War Veterans
This study looked at the association between Persian Gulf War illness and stress among women who served in the Persian Gulf War.

Physiological Responding in Posttraumatic Stress Disorder
This study examined combat veterans from the Vietnam and Persian Gulf Wars with and without post traumatic stress disorder.

Prospective Assessment of Neurocognition in Future Gulf-deployed and Gulf-nondeployed Military Personnel: A Pilot Study
This study compared pre and post-deployment health status of military personnel deployed to the Middle East. (See also VA-88)

Psychobiologic Alterations in Persian Gulf War Veterans with and without PTSD
This study compared brain functions of Vietnam veterans to Gulf War veterans.

Psychobiological Assessment of Desert Storm Veterans
This study was designed to evaluate the relationship between post-traumatic stress disorder and physical symptoms in Gulf War veterans.

Psychological Adjustment in Operation Desert Shield/Storm Veterans
This study looked at the mental health effects of military service in Operations Desert Shield/Desert Storm.

Psychological Assessment of Operation Desert Storm Returnees
This study compared post-war mental health symptoms between a group of Gulf War returnees to a group of troops from the same units who did not deploy.

Psychological Health Screening: Methods and Metrics for Deployed Forces
This study was designed to develop and test a mental health screening tool for soldiers throughout their deployment cycle.

Psychological Test Data of Gulf War Veterans Over Time
This project was designed to learn more about mental stress and physical symptoms experienced by Gulf War veterans.

Psychological Test Data of Gulf War Veterans Over Time
This project was designed to learn more about mental stress and physical symptoms experienced by Gulf War veterans.

Psychological and Neurobiological Consequences of the Gulf War Experience
This study looked at the effects of stress from war-related trauma on Gulf War veterans over time.

Psychosocial, Neuropsychological and Neurobehavioral Assessment (Project I)
This study was designed to determine if veterans had developed neurobehavioral or mental health effects from service in the Gulf War.

Quantitative Trait Genes Controlling Circadian and Sleep Behaviors
This animal study looked at mouse genes to determine which ones are responsible for how the internal clock controls sleep.

Randomized Trial of a Self-Management Early Intervention for Combat-Related PTSD
This research tested the ability of an Internet based intervention to reduce PTSD symptoms in soldiers returning from combat.

Randomized Trial of an Online Early Intervention for Combat PTSD in Primary Care
This research tested the capabilities of DESTRESS-PC, a self-management program for individuals with PTSD.

SPECT Benzodiazepine Receptor and MR Imaging in PTSD
This study was designed to use an imaging technique to compare brain functions between Vietnam and Gulf War veterans with post-traumatic stress disorder.

Stress Symptoms and Their Causal Attribution in Desert Storm Veterans
This study tested individuals from reserve units for symptoms related to post-traumatic stress disorder.

The Efficacy of Virtual Reality in Treating PTSD in Warfighters Returning from Iraq and Afghanistan Combat Theaters
This project tested the effectiveness of early treatment of combat-related PTSD through the use of virtual reality technology.

The General Well-Being of Gulf War Era Service Personnel from the States of Pennsylvania and Hawaii: A Survey
This study reviewed the effects of the Gulf War on the mental health and adjustment of military personnel in Hawaii and Pennsylvania who either deployed or did not deploy.

Traumatic Experiences Persistently Enhance Cue-dependent Learning: Toward an Animal Model of Chronic Stress and Posttraumatic Stress Disorder
This animal study looked at the relationship between repeated exposures to stressful events and the development of stress-related mental illness.

Treatment of PTSD-Related Anger in Troops Returning From Hazardous Deployments
This study tested the effectiveness of a cognitive-behavioral anger intervention for military personnel returning from deployment with PTSD-related anger problems.

Troops Exposed to Nerve Agents at Aberdeen Proving Ground: Follow-Up
This was a follow-up study reporting on the health of U.S. Army soldiers who were exposed to chemical warfare and other agents between 1955 and 1975.

Use of Virtual Reality Warfighter Scenarios with Returning Gulf War and Afghanistan Combatants Experiencing Symptoms of Acute Stress Response and PTSD
This project tested the ability of a virtual reality therapy to treat acute PTSD and combat stress in active duty military members.




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