Information Paper

 

Impact of Laboratory Performance of Urine Uranium Analyses on Exposure Evaluations for Gulf War Veterans

 

Information Papers are reports of what the Department of Defense knows today about issues potentially impacting the health of deployed military personnel. This particular information paper presents an assessment of the impact of laboratory performance for urine uranium analyses. It is not an investigative report, but is a report of an independent laboratory assessment program. If you have any information that would help better explain urine uranium analysis, please call:

1-800-497-6261

 

William Winkenwerder, Jr., MD
Assistant Secretary of Defense (Health Affairs) and
Special Assistant to the Under Secretary of Defense (Personnel and Readiness)
for Gulf War Illnesses, Medical Readiness, and Military Deployments
Department of Defense

2002024-0000003 Ver. 1.0

Last Update: October 18, 2002

Many veterans of the Gulf War have expressed concern that their unexplained illnesses may have resulted from their experiences in that war. In response to veterans’ concerns, the Department of Defense established a task force in June 1995 to investigate incidents and circumstances relating to possible causes. The Special Assistant to the Deputy Secretary of Defense for Gulf War Illnesses took over responsibility for these investigations on November 12, 1996. Effective April 5, 2001, the Special Assistant to the Under Secretary of Defense (Personnel and Readiness) for Gulf War Illnesses, Medical Readiness, and Military Deployments assumed continued responsibility for Gulf War issues.

To inform the public about the progress of its efforts, the Department of Defense publishes on the Internet and elsewhere accounts that may contribute to the discussion of the health of deployed personnel, along with documentary evidence or personal testimony used in compiling the accounts. This information paper will aid in understanding the capabilities and limitations of certain methods of measuring uranium and depleted uranium in urine, and their impact on evaluating exposures.

TABLE OF CONTENTS

I. SUMMARY

II. BACKGROUND
A. Evaluation of Depleted Uranium Exposure
1. Depleted Uranium Properties
2. Uranium in the Environment
3. Urinary Excretion
a. Urinary Excretion from Normal Air, Food and Water
b. Urinary Excretion from Exposures
B. Analytical Methods Available for Uranium
C. Interpretation of Laboratory Results
D. Laboratory Certification Processes

III. EVALUATION PROCESS
A. How It Was Done
B. Participating Laboratories
C. Evaluation Methodology (or Standards)
1. American National Standards Institute Guidelines
2. Regression Analysis

IV. RESULTS AND DISCUSSION
A. Evaluation of the Preparation Blank
B. Results by Laboratory
1. Evaluation Against American National Standard HPS N13.30-1996 Criteria
2. Evaluation by Regression Analysis
C. Results by Method
D. Assessing Exposure to Uranium
E. Impact on Identifying Depleted Uranium Exposures

V. CONCLUSIONS AND RECOMMENDATIONS

TAB A – Acronyms, Abbreviations, and Glossary

TAB B – Bibliography

END NOTES

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